GSK481CAS号： 1622849-58-4分子式： C21H19N3O4分子量： 377.39描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)参考文献
| 产品描述 | |
| 描述 |
GSK481 is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
GSK-481
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO : ≥ 35 mg/mL (92.74 mM)
|
| 生物活性 | |
| 靶点 |
RIP1
|
| In vitro(体外研究) |
GSK481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells. GSK481 has approximately equivalent RIP1 FP potencies against human and cynomolgus monkey RIP1 but was >100-fold less potent against nonprimate RIP.
|
| 参考文献 | |
| 参考文献 |
[1] Harris PA, et al. J Med Chem. 2016, 59(5):2163-2178. |
分子结构图
