MS436CAS号： 1395084-25-9分子式： C18H17N5O3S分子量： 383.42描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
MS-436; MS 436
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO: 25.5 mg/mL
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| 生物活性 | |
| 靶点 |
BRD4 (1),BRD4 (2)
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| In vitro(体外研究) |
MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages without siginificanty inhibition on cell viability.
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分子结构图
