DK419CAS号： 2102672-22-8分子式： C16H8ClF6N3O分子量： 407.7描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:80 mg/mL (196.22 mM)
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| 生物活性 | |
| In vitro(体外研究) |
DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally[1].
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| In vivo(体内研究) |
DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally[1].
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