Verapamil hydrochlorideCAS号： 152-11-4分子式： C27H38N2O4.HCl分子量： 491.06描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.
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| 纯度 |
99%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
盐酸维拉帕米；(±)-Verapamil hydrochlorid
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| 外观 |
白色粉末
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| 可溶性/溶解性 |
DMSO ：98mg/mL(199.56mM)
Water ：50mg/mL(101.82mM) Ethanol ：12mg/mL(24.43mM) |
| 生物活性 | |
| 靶点 |
Calcium channel
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| In vitro(体外研究) |
The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).
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| In vivo(体内研究) |
Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.
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| 参考文献 | |
| 参考文献 |
[1] Yanjiao X, et al. Drug Metab Pharmacokinet, 2013. [2] Zhou P, et al. PLoS One, 2013, 8(8), e71567. |
分子结构图
