Bcl-2 Inhibitor II, YC137CAS号： 810659-53-1分子式： C24H21N3O6S2分子量： 511.6描述应用储存/保存方法形态别名外观密度折射率Ki 数据可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
Bcl-2 Inhibitor II, YC137 is a cell-permeable naphthoquinone compound that selectively induces apoptosis of Bcl-2-overexpressing cells (< 300 nM in MDA-MB435B breast cancer cells) with little effect on a variety of primary cells. Bcl-2 Inhibitor II, YC137 preferentially binds Bcl-2 (Ki = 1.3 μM) and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. This has shown to induce the release of cytochrome c from mitochondria as well as activate caspase-9. |
| 应用 |
A naphthoquinone inducer of apoptosis
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 形态 |
Solid
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| 基本信息 | |
| 别名 |
YC 137；YC-137
|
| 外观 |
Red solid
|
| 密度 |
1.44 g/cm3 (Predicted)
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| 折射率 |
n20D 1.67 (Predicted)
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| Ki 数据 |
Bcl-2: Ki= 1.3 µM
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| 可溶性/溶解性 |
Soluble in DMSO (5 mg/ml), and methanol (5 mg/ml).
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| PubChem CID |
6918811
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分子结构图
