APX-115CAS号： 1395946-75-4分子式： C17H18ClN3O分子量： 315.80描述纯度储存/保存方法别名可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
Ewha 18278；APX 115；APX115
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| 可溶性/溶解性 |
DMSO : ≥ 250 mg/mL (791.64 mM)
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| 生物活性 | |
| In vitro(体外研究) |
APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line.
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| In vivo(体内研究) |
APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice.
APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. |
分子结构图
