S18986 is a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that potently enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices.¹ S18986 is orally bioavailable and penetrates the blood-brain barrier in animals.² Formulations containing S18986 improve episodic memory in rats.² S18986 is used to elucidate the roles of AMPA receptor signaling in cells and in animals.^2,3,4

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1.Lockhart, B.,Iop, F.,Closier, M., et al. (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [³H]noradrenaline release from rat hippocampal and frontal cortex slices. Eur. J. Pharmacol. 401(2), 145-153 (2000).

2.Lebrun, C.,Pillière, E. and Lestage, P. Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. Eur. J. Pharmacol. 401(2), 205-212 (2000).

3.Vandesquille, M.,Carrié, I.,Louis, C.F., et al. Effects of positive modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors in a benzodiazepine-induced deficit of spatial discrimination in mice. J. Psychopharmacol. 26(6), 845-856 (2012).

4.Yefimenko, N.,Portero-Tresserra, M.,Martí-Nicolovius, M., et al. The AMPA receptor modulator S18986 in the prelimbic cortex enhances acquisition and retention of an odor-reward association. Neurosci. Lett. 548, 105-109 (2013).