MRT68921 hydrochlorideCAS号： 1190379-70-4(freebase)分子式： C25H34N6O·xHCl分子量： 434.58 (free base)描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)参考文献
| 产品描述 | |
| 描述 |
MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO ：10 mg/mL (23.01 mM)
|
| 生物活性 | |
| 靶点 |
ULK1,ULK2
|
| In vitro(体外研究) |
MRT68921 specifically disrupts autophagosome maturation and thus blocks autophagic flux through ULK1 inhibition.
|
| 参考文献 | |
| 参考文献 |
[1] Petherick KJ, et al. J Biol Chem. 2015, 290(18), 11376-11383. |
分子结构图
