GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.

97%

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VEGFR2:120 nM, human CDK9:10 nM, human CDK2:1.9 nM, SRC:930 nM, human CDK4:300 nM, yeast Cdk1:20 nM, yeast Pho85:400 nM, human CDK1:30 nM

GW297361 (20 μM; 15 min; YRP1 cells) partially inhibits intracellular Cdk1.[1]