ICA 069673CAS号： 582323-16-8分子式： C11H6ClF2N3O分子量： 269.63描述应用储存/保存方法形态别名密度熔点沸点折射率IC50PK值可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). No meeasurable activity was displayed over a variety of cardiac ion channels.
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| 应用 |
A selective activator of the KCNQ2/Q3 potassium channel
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| 储存/保存方法 |
Store at room temperature
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
N-(2-Chloro-5-pyrimidinyl)-3,4-difl uorobenzamide
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| 密度 |
~1.5 g/cm3 (Predicted)
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| 熔点 |
167.15° C (Predicted)
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| 沸点 |
~358.9° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.63 (Predicted)
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| IC50 |
Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3): EC5050 = 0.69 µM (human); HERG: IC50 >30 µM (human); Na+ CP type Vα: IC50 >30 µM (human)
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| PK值 |
pKa: 9.47 (Predicted)
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| 可溶性/溶解性 |
Soluble in DMSO (100 mM), and ethanol (25 mM).
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| MDL |
MFCD20926351
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| PubChem CID |
10149311
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