CAY10595 is a mixture of isomers which acts as a potent CRTH2/DP₂ receptor antagonist (Ki = 10 nM). The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on eosinophils, basophils and Th2 cells where it mediates the chemotactic activity of PGD2.

A CRTH2/DP2 receptor antagonist

Store at -20° C

5-chloro-1′-[5-chloro-2-fluorophenyl)methyl]-2,2′,5′-trioxo-spiro[3H-indole-3,3’pyrrolidine]-1(2H)-acetic acid

A crystalline solid