AMG 487CAS号： 473719-41-4分子式： C32H28F3N5O4分子量： 603.59描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
AMG-487
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| 外观 |
White to yellow solid
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| 可溶性/溶解性 |
DMSO : ≥ 41 mg/mL
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| 生物活性 | |
| 靶点 |
CXCR
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| In vivo(体内研究) |
AMG 487 (0.03-10 mg/kg, s.c.) exhibits significant reduction in cellular infiltration into the lungs in a dose dependent manner. AMG487 (5 mg/kg, s.c., twice daily) develops fewer metastases than that in vehicle-treated mice. AMG487 (5 mg/kg, s.c.)-treated mice exhibits fewer pulmonary nodules than the control mice in both the models. AMG487 reduces the tumour volume.
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分子结构图
