3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide inhibits human ACAT-1 and ACAT-2 (Acyl-Coenzyme A cyltransferase-1 and -2) equally with an IC₅₀ of about 60 μM. ACAT-1 and ACAT-2 catalyze the formation of long chain fatty acyl-coenzyme A and cholesterol esters from cholesterol, and may play a role in the development of atherosclerosis. This chemical inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively and also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.

A cholesterol acyltransferase-1 and -2 inhibitor

Store at -20° C

Solid

3,4-DIHYDROXY HYDROCINNAMIC ACID (L-ASPARTIC ACID DIBENZYL ESTER) AMIDE;CAY10485;N-[3-(3,4-DIHYDROXYPHENYL)-1-OXOPROPYL]-L-ASPARTIC ACID, BIS(PHENYLMETHYL) ESTER

Crystalline

~1.3 g/cm³ (Predicted)

~727.6° C at 760 mmHg (Predicted)

n²⁰_D 1.61 (Predicted)

Antioxidant activity against copper mediated low-density lipoproteins oxidation: IC₅₀ = 3 µM (human); SOAT1: IC₅₀ = 60 µM (human); SOAT2: IC₅₀ = 81 µM (human)

pK_a: 9.77 (Predicted)

Soluble in water (0.25 mg/ml at 25° C), ethanol (~ 20 mg/ml), DMSO (~ 20 mg/ml), DMF (~ 20 mg/ml), and 1: 3 solution of ethanol:PBS (pH 7.2) (~ 0.25 mg/ml).

MFCD08062181

35026724