BMS 794833CAS号： 1174046-72-0分子式： C23H15ClF2N4O3分子量： 468.84描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BMS-794833是一种有效的，ATP竞争性Met/VEGFR2抑制剂，IC50为1.7 nM/15 nM，也抑制Ron， Axl和Flt3，IC50低于3 nM；是BMS-817378的前体药物。BMS794833也抑制Met受体激活的胃癌细胞系GTL-16, IC50 为39 nM。 |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO ：87 mg/mL (185.6 mM)
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| 生物活性 | |
| 靶点 |
Met,VEGFR2
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| In vitro(体外研究) |
BMS794833 also inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with IC50 of 39 nM.
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| In vivo(体内研究) |
In GTL-16 human gastric tumor xenografts model, BMS798433 shows greater than 50% TGI for at least one tumor doubling time with no overt toxicity observed during 14 days. BMS798433 also shows complete tumor stasis at a dose of 25 mg/kg against U87 glioblastoma model.
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分子结构图
