MPI-0479605CAS号： 1246529-32-7分子式： C22H29N7O分子量： 407.51描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
MPI-0479605,MPI 0479605,MPI0479605
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 62 mg/mL warmed (152.14 mM)
Ethanol 2 mg/mL warmed (4.9 mM) |
| 生物活性 | |
| 靶点 |
Mps1
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| In vitro(体外研究) |
MPI-0479605 impairs the SAC and the bipolar attachment of chromosomes to the mitotic spindle, which results in chromosome segregation defects and aneuploidy. MPI-0479605 results in a significant decrease in cell viability with GI50 ranging from 30 to 100 nM in a panel of tumor cell lines. In addition, MPI-0479605 also causes cell growth arrest and ultimately promotes cell death by apoptosis or mitotic catastrophe.
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| In vivo(体内研究) |
MPI-0479605 (30 mg/kg daily or 150 mg/kg every 4 days, i.p.) shows antitumor activity in colon cancer xenograft models.
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分子结构图
