A-1210477

A-1210477CAS号: 1668553-26-1分子式: C46H55N7O7S分子量: 850.04描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)参考文献

产品描述
描述

A-1210477 is a potent and selective MCL-1 and Bcl-2 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.

纯度
99%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
10 mM in DMSO
生物活性
靶点
MCL-1
In vitro(体外研究)
In H929 cells, A-1210477 binds to MCL-1 with high affinity and induces MCL-1 protein elevation. In H929, H2110, and H23 cells, A-1210477 induce the hallmarks of apoptosis, and inhibits MCL-1-dependent cell viability. A-1210477 also synergizes with navitoclax to kill a variety of cancer cell lines. In SKBR3 cells, A-1210477 inhibits MCL-1–BIM interaction and induces classical features of apoptosis. In addition, A-1210477 sensitizes non-Hodgkin’s lymphoma cell lines to venetoclax (ABT-199).
参考文献
参考文献
  • 1. Bruncko M, et al. J Med Chem. 2015 Mar 12;58(5):2180-2194.
  • 2. Leverson JD, et al. Cell Death Dis. 2015 Jan 15;6:e1590.
  • 分子结构图

    A-1210477