BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

KRAS-SOS1:7 nM

BI-0474 (1-10,000 nM; 3 days; NCI-H358 cells carrying a G12C mutation) inhibited proliferation of NCI-H358 cells with an EC50 of 26 nM.[1]

BI-0474 (40 mg/kg; i.p.; single daily for 3 days; NMRI nude mice) shows anti-tumor efficacy and pharmacodynamic biomarker modulation. This led to the induction of programmed cell death in this xenograft model.[1]