XEN445CAS号： 1515856-92-4分子式： C18H17F3N2O3分子量： 366.33描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
XEN445 is a potent and selective EL inhibitor (IC50=0.237 uM) which shows good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.XEN445 can be readily prepared in good yield from commercial available chemicals, which is selected for further evaluation of this series of EL inhibitors. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
XEN-445
|
| 外观 |
White to light yellow powder
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| 可溶性/溶解性 |
DMSO : ≥ 40 mg/mL (109.19 mM)
|
| 生物活性 | |
| 靶点 |
endothelial lipase
|
| In vitro(体外研究) |
XEN445 shows good in vitro inhibitory potency against EL, and high selectivity over LPL and HL.
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| In vivo(体内研究) |
XEN445 displays good ADME and PK properties. In mice, XEN445 (30 mg/kg, p.o.) raises plasma HDL-cholesterol concentration.
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分子结构图
