Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome.¹ Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC₅₀ of 5 µM.² These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.

≥98%

Store at -20℃

1.Cecconi, F.,Alvarez-Bolado, G.,Meyer, B.I., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737 (1998).

2.Nguyen, J.T. and Wells, J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proceedings of the National Academy of Sciences of the United States of America 100(13), 7533-7538 (2003).