NCGC00378430CAS号： 920650-00-6分子式： C22H23N3O5S分子量： 441.5描述纯度储存/保存方法可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:90 mg/mL (203.85 mM)
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| 生物活性 | |
| In vitro(体外研究) |
NCGC00378430 reduces the SIX1/EYA2 interaction.?8430 partially reversed transcriptional and metabolic profiles mediated by SIX1 overexpression and reversed SIX1-induced TGFβ signaling and EMT.
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| In vivo(体内研究) |
NCGC00378430?was well tolerated when delivered to mice and significantly suppressed breast cancer associated metastasis in vivo without significantly altering primary tumor growth.
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