OICR-9429CAS号： 1801787-56-3分子式： C29H32F3N5O3分子量： 555.59描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
OICR-9429是一个新颖的相互作用的小分子Wdr5-MLL拮抗剂，IC50是5 uM，能够抑制增殖。 |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
OICR9429; OICR 9429
|
| 外观 |
white to light brown powder
|
| 可溶性/溶解性 |
DMSO 38 mg/mL (68.39 mM)
Ethanol 15 mg/mL (26.99 mM) Water slightly soluble or insoluble |
| 生物活性 | |
| 靶点 |
Wdr5-MLL interaction,WDR5
|
| In vitro(体外研究) |
OICR-9429 binds WDR5 with high affinity (Kd=93±28 nM) and competitively disrupts its interaction with a high-affinity Wdr5-interacting (WIN) peptide of MLL (Kdisp=64±4 nM).
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分子结构图
