EO 1428 is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase. EO 1428 is described to inhibit the p38α and p38β isoforms of the kinase by occupying the ATP-binding cleft. This inhibition is described to potently block the release of TNF-α (IC₅₀ = 5 nM) and the proinflammatory interleukins IL-1β, IL-6, IL-8, and IL-10 (IC₅₀s = 30, 17, 4, 74 nM).

>97%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

p38 MAP Kinase Inhibitor VIII

Yellow solid

1.48 g/cm³ (Predicted)

219.29° C (Predicted)

515.94° C at 760 mmHg (Predicted)

n²⁰_D 1.69

p38α: IC₅₀ = 40 nM; IL-8: IC₅₀ = 4 nM; TNF-α: IC₅₀ = 5 nM; IL-6: IC₅₀ = 17 nM; IL-1β: IC₅₀ = 30 nM; IL-10: IC₅₀ = 74 nM

pK_b: 4.03 (Predicted)

Soluble in DMSO (100 mM), and ethanol (50 mM).

MFCD11100188

9801969

p38α,p38β2