Ki-16425CAS号： 355025-24-0分子式： C23H23ClN2O5S分子量： 474.96描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
Ki-16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
Debio 0719；Ki16425
|
| 外观 |
white powder
|
| 可溶性/溶解性 |
DMSO : ≥ 100 mg/mL (210.54 mM)
|
| 生物活性 | |
| 靶点 |
LPL Receptor
|
| In vitro(体外研究) |
Ki-16425 (10 μM; 1.5 hours; HEK293A cells) treatment blocks LPA-induced dephosphorylation of YAP/TAZ in HEK293A cells. Ki16425 partially inhibits the ability of serum to repress YAP/TAZ phosphorylation, particularly at low serum concentrations (0.2%).
|
| In vivo(体内研究) |
Ki-16425 (Debio 0719) (1-30 mg/kg; i.p.; at 30 min prior to LPA injection) inhibits LPA-induced neuropathic pain-like behaviors.
|
分子结构图
