The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC₅₀ = 70 nM), compared to PI3Kα (IC₅₀ = 240 nM), PI3Kβ (IC₅₀ = 1.45 μM), and PI3Kδ (IC₅₀ =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED₅₀ = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

S 041164

Soluble in DMSO (~25 mg/ml), dimethyl formamide (~25 mg/ml), and 1:9 ethanol:PBS(pH 7.2) (~0.1 mg/ml).

1.Hirsch, E.,Ciraolo, E.,Ghigo, A., et al. Taming the PI3K team to hold inflammation and cancer at bay. Pharmacology & Therapeutics 118, 192-205 (2008).

2.Ferrandi, C.,Ardissone, V.,Ferro, P., et al. Phosphoinositide 3-kinase γ inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. Journal of Pharmacology and Experimental Therapeutics 322, 923-930 (2007).