PDGFR Tyrosine Kinase Inhibitor IV is a indenopyrazole compound that displays potent antiproliferative properties in human tumor cell lines. It acts as a reversible ATP-competitive inhibitor of PDGFR but exhibits less actibity towards Lck, c-Src, and Fyn while exhibiting little to no inhibition toward VEGFR, HER-2, Cdk’s-1,-2,-4 &-7, bFGFR-1 and EGFR. PDGFR Tyrosine Kinase Inhibitor IV is cell-permeable. PDGFR Tyrosine Kinase Inhibitor IV is an inhibitor of c-Abl, PDGFR-α and PDGFR-β.

An indenopyrazole agent that displays potent antiproliferative properties

>98%

Store at -20° C

Solid

~1.37 g/cm³ (Predicted)

154° C

~528.77° C at 760 mmHg (Predicted)

n²⁰_D 1.67

pK_a: 14.00, pK_b: 3.10

Soluble in DMSO (>10 mg/ml), water (<2 mg>

9797370