SKF 38393 hydrochlorideCAS号： 62717-42-4分子式： C16H17NO2 . HCl分子量： 291.77描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SKF38393 HCl is a selective dopamine D1/D5 receptor agonist. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
SKF 38393 hydrochloride；(±)-SKF-38393 hydrochloride；SKF-38393A
|
| 外观 |
white powder
|
| 可溶性/溶解性 |
DMSO : 54 mg/mL (185.1 mM)
Ethanol ：6 mg/mL (20.56 mM), warmed |
| 生物活性 | |
| 靶点 |
dopamine D1 receptor,D5 receptor
|
| In vitro(体外研究) |
SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.
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| In vivo(体内研究) |
SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.
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分子结构图
