DEL-22379CAS号： 181223-80-3分子式： C26H28N4O3分子量： 444.53描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
DEL22379,DEL 22379,DEL-22379
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO: ≥ 30 mg/mL
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| 生物活性 | |
| 靶点 |
ERK
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| In vitro(体外研究) |
DEL-22379 inhibits ERK dimerization without affecting its phosphorylation. In a panel of human cell lines harboring mutant BRAF (V600E) or RAS (Q61L or G12V), DEL-22379 shows potent anti-proliferative effects, and induces apoptosis.
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| In vivo(体内研究) |
DEL-22379 (15 mg/kg, i.p.) prevents tumor growth and metastasis in mice bearing A375 (BRAF mutant) and HCT116 (KRAS mutant) tumors, but fails to prevent the formation of tumors in mice injected with CHL cells (WT/WT).
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分子结构图
