NS3694CAS号： 426834-38-0分子式： C15H10ClF3N2O3分子量： 358.70描述纯度储存/保存方法形态别名外观密度熔点沸点折射率IC50PK值可溶性/溶解性MDLPubChem CIDIn vitro(体外研究)
| 产品描述 | |
| 描述 |
NS3694 inhibits apoptosome formation and caspase activation.
The release of mitochondrial proapoptotic proteins into the cytosol is a critical event in apoptosis signaling, resulting in the activation of caspases. Once in the cytosol, cytochrome c triggers the formation of a caspase-activating protein complex called the apoptosome, while Smac/Diablo and Omi/htra2 antagonize the caspase inhibitory effect.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
Apoptosis Inhibitor II
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| 外观 |
solid
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| 密度 |
~1.6 g/cm3 (Predicted)
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| 熔点 |
204.67° C (Predicted)
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| 沸点 |
~378.4° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.64 (Predicted)
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| IC50 |
TNF-α-induced death: IC50 = 50 µM (MCF-casp3 cells); Glutamate receptor ionotropic kainate 1: IC50 = 5 µM (human)
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| PK值 |
pKa: 3.32 (Predicted)
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| 可溶性/溶解性 |
DMSO : 22 mg/mL
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| MDL |
MFCD00249000
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| PubChem CID |
10109069
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| 生物活性 | |
| In vitro(体外研究) |
Previous study found that NS3694, and its two analogs (NS1764 and NS1784) were well-tolerated by MCF-7S1 breast cancer cells at concentrations up to 100, 50, and 25 μM, respectively. Moreove, all three compounds could not inhibit recombinant caspase 9 and caspase 3 at concentrations ranging from 25 to 100 μM. In addition, NS3694 was able to inhibit the co-immunoprecipitation of caspase 9 and Apaf-1 from HeLa cell cytosol stimulated by cytochrome c and dATP. NS3694 could also inhibit the formation of the active 700-kDa apoptosome complex, but had no effect on TNF-induced caspase-independent death of WEHI-S cells. NS3694 did not inhibit FasL-induced caspase activation or death in type I cells neither.
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分子结构图
