A-366CAS号： 1527503-11-2分子式： C19H27N3O2分子量： 329.44描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
A-366；A366；A 366
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO : 32.9 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
G9a/GLP
|
| In vitro(体外研究) |
A-366 has significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2.Treatment of various leukemia cell lines in vitro results in marked differentiation and morphological changes of these tumor cell lines.
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| In vivo(体内研究) |
Treatment of a flank xenograft leukemia model with A-366 results in growth inhibition consistent with the profile of H3K9me2 reduction observed.
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分子结构图
