360A iodideCAS号： 737763-37-0分子式： C27H23I2N5O2分子量： 703.31描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
360A is a strong affinity and selectivity inhibitor of G-quadruplex structures. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
360 A iodide
|
| 可溶性/溶解性 |
DMSO : 2 mg/mL (2.84 mM; Need ultrasonic)
|
| 生物活性 | |
| 靶点 |
G-quadruplex
|
| In vitro(体外研究) |
360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.
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分子结构图
