LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM).

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

DMSO:175 mg/mL (441.43 mM)

AAK1:0.9 nM(Ki), AAK1:3.3 nM, GAK:320 nM, BIKE:14 nM