AZ3451CAS号： 2100284-59-9分子式： C30H27BrN4O3分子量： 571.46描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
AZ3451 is a potent protease-activated receptor-2 (PAR2) antagonist with IC50 of 23 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
AZ 3451
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| 可溶性/溶解性 |
DMSO : ≥ 83.3 mg/mL (145.77 mM)
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| 生物活性 | |
| 靶点 |
Protease-activated receptor-2
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| In vitro(体外研究) |
Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle of the protease-activated receptor 2. AZ3451 is highly lipophilic, which coincides with the hydrophobic nature of the binding pocket within the membrane. Antagonist binding prevents structural rearrangements required for receptor activation and signalling.
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分子结构图
