Venezuelan Equine Encephalitis Virus (VEEV) is a mosquito-borne alphavirus that can cause encephalomyelitis in all equine species and also in humans. ML-336 is a quinazolinone-based compound that has been shown to inhibit a VEEV-induced cytopathic effect in three strains of the virus (IC₅₀s = 32, 20, and 41 nM for TC-83, V3526, and Trinidad donkey strains, respectively).¹ It is reported to target the VEEV non-structural protein 2, which is necessary for transcription and replication of viral RNA.¹

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1.Chung, D.,Schroeder, C.E.,Sotsky, J., et al. ML336: Development of quinazolinone-based inhibitors against Venezuelan Equine Encephalitis Virus (VEEV). 1-27 (2012).