A-1331852CAS号： 1430844-80-6分子式： C38H38N6O3S分子量： 658.81描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
A 1331852；A1331852
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO : ≥ 50 mg/mL (75.89 mM)
|
| 生物活性 | |
| 靶点 |
Bcl-xL
|
| In vitro(体外研究) |
A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at lownanomolar concentrations as early as 1 h post-treatment.
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| In vivo(体内研究) |
A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent.
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分子结构图
