MK-3328CAS号： 1201323-97-8分子式： C14H9FN4O分子量： 268.25描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer’s disease.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:<10mM
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| 生物活性 | |
| 靶点 |
β-Amyloid:10.5 nM
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| In vitro(体外研究) |
MK-3328 displays amyloid binding potency balanced with low levels of nonspecific binding.[1]
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| In vivo(体内研究) |
In normal rhesus monkey positron emission tomography (PET) imaging studies, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake, and good washout.[2]
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