SL-327CAS号: 305350-87-2分子式: C16H12F3N3S分子量: 335.35描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
SL-327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier. |
纯度 |
>98%
|
储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
|
基本信息 | |
别名 |
SL327;SL 327;Mek-1/Mek-2 Inhibitor
|
外观 |
white solid
|
可溶性/溶解性 |
DMSO : 68 mg/mL (202.77 mM; Need ultrasonic)
|
生物活性 | |
靶点 |
MEK1;MEK2,AP-1
|
In vitro(体外研究) |
SL-327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL-327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII.
|
In vivo(体内研究) |
SL-327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. SL-327 (30 mg/kg) significantly impairs spatial learning in mice. SL-327 (50 mg/kg) blocks cocaine-induced properties.
|
分子结构图