SL-327

SL-327CAS号: 305350-87-2分子式: C16H12F3N3S分子量: 335.35描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)

产品描述
描述

SL-327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.

纯度
>98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
别名
SL327;SL 327;Mek-1/Mek-2 Inhibitor
外观
white solid
可溶性/溶解性
DMSO : 68 mg/mL (202.77 mM; Need ultrasonic)
生物活性
靶点
MEK1;MEK2,AP-1
In vitro(体外研究)
SL-327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL-327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII.
In vivo(体内研究)
SL-327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. SL-327 (30 mg/kg) significantly impairs spatial learning in mice. SL-327 (50 mg/kg) blocks cocaine-induced properties.

分子结构图

SL-327