ML-324CAS号： 1222800-79-4分子式： C21H23N3O2分子量： 349.43描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC50 = 920 nM) |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
ML-324，ML324，ML 324
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO ：43 mg/mL warmed (123.05 mM)
Ethanol ：3 mg/mL warmed (8.58 mM) |
| 生物活性 | |
| 靶点 |
JMJD2
|
| In vitro(体外研究) |
ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.
|
| In vivo(体内研究) |
In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation.
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分子结构图
