AZ304CAS号： 942507-42-8分子式： C27H25N5O2分子量： 451.52描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
AZ-304
|
| 可溶性/溶解性 |
DMSO : 125 mg/mL (276.84 mM; Need ultrasonic)
|
| 生物活性 | |
| 靶点 |
BRAF
|
| In vitro(体外研究) |
BRafV600E38 nM (IC50)BRAFWT79 nM (IC50)CRAF68 nM (IC50)p386 nM (IC50)CSF1R35 nM (IC50)MAP3K76400 nM (IC50)CSK7050 nM (IC50)
|
分子结构图
