CH5138303CAS号： 959763-06-5分子式： C19H18ClN5O2S分子量： 415.9描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:83 mg/mL (199.56 mM)
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| 生物活性 | |
| 靶点 |
HSP90α
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| In vitro(体外研究) |
CH5138303 shows high affinity to Hsp90αand potent cell growth inhibitory activity against an HCT116 colorectal cancer cell line and an NCI-N87 gastric cancer cell line with IC50 of 98 nM and 66 nM, respectively. Besides, CH5138303 also demonstrates liver microsomal stability.
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| In vivo(体内研究) |
CH5138303 (50 mg/kg p.o.) displays high oral bioavailability in mice and produces potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model.
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| 参考文献 |
分子结构图
