GSK2801CAS号： 1619994-68-1分子式： C20H21NO4S分子量： 371.45描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GSK2801 is a very potent inhibitor of the BAZ2 family of bromodomain containing proteins.
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| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
GSK-2801, GSK 280
|
| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 74 mg/mL warmed (199.21 mM)
Ethanol 7 mg/mL warmed (18.84 mM) |
| 生物活性 | |
| 靶点 |
BAZ2B ,BAZ2A
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| In vitro(体外研究) |
In U2OS cells transfected with mutant BAZ2A (N1873F), GSK2801 (1 μM) accelerates FRAP half-recovery time by displacing BAZ2A from chromatin.
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| In vivo(体内研究) |
In male CD1 mice, GSK2801 (30 mg/kg, p.o. and i.p.) has reasonable in vivo exposure after oral dosing, modest clearance, and reasonable plasma stability.
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分子结构图
