AP26113-analogCAS号: 1197958-12-5分子式: C26H34ClN6O2P分子量: 529.01描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
产品描述 | |
描述 |
AP26113-analog (ALK-IN-1) is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR. |
纯度 |
>98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
布格替尼类似物;ALK-IN-1;AP26113
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外观 |
Light yellow powder
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可溶性/溶解性 |
Ethanol :98 mg/mL (185.3 mM)
DMSO :42 mg/mL (79.4 mM) |
生物活性 | |
靶点 |
ALK
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In vitro(体外研究) |
Brigatinib and AP26113-analog have similar potency against the triple-mutant EGFR with IC50 values of <100 nM. AP26113-analog suppresses phosphorylation of EGFR and its downstream signalling pathway in cells expressing all types of EGFR mutations.
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分子结构图