CFI402257CAS号： 1610759-22-2分子式： C28H30N6O3分子量： 498.58描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
CFI-402257 is a highly potent and selective TTK (threonine tyrosine kinase) Inhibitor ((TTK Ki = 0.1 nM) with potential anticancer activity.
|
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
CFI402257；CFI 402257；CFI-402257
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
10 mM in DMSO
|
| 生物活性 | |
| 靶点 |
Mps1
|
| In vivo(体内研究) |
The upper dose level for once-daily administration of CFI-402257 is between 6 and 6.5 mg/kg. CFI-402257 given orally QD shows dose-dependent activity in mice with established tumors from xenografted MDA-MB-231 human TNBC cells , from xenografted MDA-MB-468 human TNBC cells in mice (5 mg/kg, TGI=75%; 6 mg/kg, TGI=94%). CFI-402257 also demonstrates antitumor activity in a platinum-resistant PDX model of high-grade serous ovarian cancer (6.5 mg/kg, TGI=61%). CFI-402257 is found to be similarly efficacious in a platinum-sensitive PDX model of high-grade serous ovarian cancer.
|
分子结构图
