Enasidenib mesylateCAS号： 1650550-25-6分子式： C20H21F6N7O4S分子量： 569.48描述纯度储存/保存方法别名外观可溶性/溶解性In vitro(体外研究)
| 产品描述 | |
| 描述 |
Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
AG221甲磺酸盐；AG-221 mesylate
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| 外观 |
White powder
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| 可溶性/溶解性 |
DMSO : ≥ 100 mg/mL (175.60 mM)
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| 生物活性 | |
| In vitro(体外研究) |
Enasidenib (AG-221) reverses the effects of mutant IDH2 on DNA methylation in mutant stem/progenitor cells. Enasidenib induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells, effects that are further enhanced by simultaneous inhibition of Flt3ITD. Enasidenib (AG-221) therapy induces differentiation of leukemic cells, with an increase in the CD11b+ population and a decrease in the c-Kit+ population in the peripheral blood at 2 wks.
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分子结构图
