DMU-212

DMU-212CAS号: 134029-62-2分子式: C18H20O4分子量: 300.35描述储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)

产品描述
描述
DMU-212, a methylated form of Resveratrol, shows antimitotic, antiproliferative, and antioxidant activities. DMU-212 induces mitotic arrest through the activation of ERK1/2 protein and the promotion of apoptosis.
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:20 mg/mL (66.59 mM)
生物活性
靶点
proliferation:0.5 μM(A375), proliferation:0.5 μM(Bro), proliferation:1.25 μM(M5 human melanoma cells), proliferation:1.25 μM(MeWo)
In vitro(体外研究)
DMU-212 (0.3125-40 μM) inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC50=0.5 μM, 0.5 μM, 1.25 μM, and 1.25 μM for A375, Bro, MeWo, and M5 human melanoma cells, respectively.)[2].
In vivo(体内研究)
In SCID female mice, DMU-212 (50 mg/kg; i.g.) inhibited tumor growth and lowered tumor burden[2].