A23187 is an ionophore, highly selective for Ca²⁺, that allows for divalent cations to move across the membranes which are usually impermeable to them. The compound was originally isolated from Streptomyces chartreusensis for use as an antibiotic but has been shown to have weak in vitro antimicrobial activity against fungi and gram positive bacteria. Because of its ability to increase intracellular calcium levels of intact cells, it is used in studies of intracellular Ca²⁺ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation.

white to light yellow solid

≥97%

A highly selective Ca²⁺ ionophore

卡西霉素; Calcimycin；A-23187；Antibiotic A-23187

~1.29 g/cm³ (Predicted)

181-182° C

~710.33° C at 760 mmHg (Predicted)

n²⁰_D 1.61 (Predicted)

pK_a: 0.33, pK_b: 8.27

Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)

C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)C3=CC=CN3)C)C)O[C@@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC

Streptomyces chartreusis

Store at -20° C，2 years.

MFCD00151202

1096801

11957499

258-084-1

3

DM4676000