Rabbit anti-IGFBP4 Recombinant Monoclonal Antibody(187-5)别名宿主反应种属应用免疫原形式浓度纯化方法类型克隆号储存/保存方法存储溶液背景说明UniProt
| 概述 | |
| 别名 |
IBP-4; IGF-binding protein 4; IGFBP-4
|
| 宿主 |
Rabbit
|
| 反应种属 |
Human
|
| 应用 |
Sandwich ELISA: JP190726 as capture antibody pair with other detection antibody, S0B3109 recognized human CT-IGFBP-4, low cross-reaction with full-length human IGFBP-4 (ELISA), (Note: 因为本产品没有图片，所以图注放在稀释比一栏）
|
| 免疫原 |
Synthetic Peptide
|
| 性能 | |
| 形式 |
Liquid
|
| 浓度 |
2 mg/mL
|
| 纯化方法 |
Protein A affinity column
|
| 类型 |
Monoclonal Antibody
|
| 克隆号 |
187-5
|
| 储存/保存方法 |
Store at 2-8℃ for one year.
|
| 存储溶液 |
PBS pH7.4, 0.03% Proclin 300
|
| 靶标 | |
| 背景说明 |
The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon cancer cells. Recent studies have indicated that IGFBP-4 fragments can predict adverse cardiac events in acute coronary syndrome patients Some inventions describes a method for diagnosing of cardiovascular diseases, which comprises detection of IGFBP-4 (insulin-like growth factor binding protein-4) fragments in patients’ blood. It provides antibodies as well as epitopes for antibodies, specific to proteolytic fragments (both N- and C-terminal) of IGFBP-4 originated from IGFBP-4 molecule after its cleavage by specific protease PAPP-A. Antibodies could be used for development of immunoassay methods for quantitative or qualitative detection of IGFBP-4 fragments in human blood.
|
| UniProt |
P22692
|