HS-173CAS号： 1276110-06-5分子式： C21H18N4O4S分子量： 422.46描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
HS-173 is a potent inhibitor of PI3Kα with IC50 value of 0.8 nM. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
HS 173；HS173
|
| 外观 |
Grey to Brown Powder
|
| 可溶性/溶解性 |
DMSO : 78 mg/mL (184.6 mM)
|
| 生物活性 | |
| 靶点 |
PI3Kα
|
| In vitro(体外研究) |
HS-173 shows potent antiproliferative effects in T47D, SK-BR3, and MCF7 cells with IC50 of 0.6, 1.5, and 7.8 μM, respectively. HS-173 causes complete suppression of the PI3K pathway in cancer cell lines (Hep3B and SkBr3). Moreover, HS-173 induces cell apoptosis by affecting cell-cycle distribution and activating caspases, and block VEGF-induced angiogenesis in vitro. Combined treatment with Sorafenib and HS-173 has a synergistic anti-cancer effect on pancreatic cancer cells.
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| In vivo(体内研究) |
HS-173 diminishes blood vessel formation in mice. HS-173 markedly attenuates the development of liver fibrosis by blocking PI3K/Akt signaling in vivo.
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分子结构图
