ML 171CAS号： 6631-94-3分子式： C14H11NOS分子量： 241.31描述纯度储存/保存方法产品用途形态别名外观可溶性/溶解性PubChem CID靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
ML171是一种有效的、选择性的NADPH-oxidase抑制剂，对NOX1、NOX2、NOX3、NOX4和xanthine oxidase的IC50分别为0.25 μM, 5 μM, 3μM, 5 μM 和 5.5 μM。
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| 纯度 |
＞98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 产品用途 |
科研试剂，医药中间体，用于解热镇痛新药消炎丙宁和乙酰嗪的制造。
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
2-乙酰基吩噻嗪；2-Acetylphenothiazine；2-APT；ML-171；ML171
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| 外观 |
yellow to orange to brown powder
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| 可溶性/溶解性 |
DMSO ：48 mg/mL (198.91 mM)
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| PubChem CID |
81131
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| 生物活性 | |
| 靶点 |
NOX1,NOX3,NOX2,NOX4,xanthine oxidas
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| In vitro(体外研究) |
ML171 is a potent and selective inhibitor of NOX1, with an IC50 of 129–156 nM in cell-based assays. ML171 is not cytotoxic, and is selective among NOX family members NOX2, NOX3, and NOX4, as well as against xanthine oxidase, another cellular source of ROS. In addition, ML171 is highly effective in inhibiting the cellular production of invadopodia in a human colon cancer cell line. It strongly blocks ROS generation in HT29 cells (IC50HT29 = 0.129 μM). ML171 does not inhibit mitochondrial ROS production.
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分子结构图
