Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

CE164抗体;Centrosomal protein of 164 kDa; Cep164; CEP164; KIAA1052; NPHP15

Rabbit

This CE164 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-274 amino acids from the N-terminal region of human CE164.

Human

WB~~1:1000
FC~~1:10~50

Predicted molecular weight: 164kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Polyclonal Antibody

Rabbit Ig

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Antibody Collections

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1

Q9UPV0

Pan, Y.R., et al. Cell Cycle 8(4):655-664(2009)
Sivasubramaniam, S., et al. Genes Dev. 22(5):587-600(2008)
Graser, S., et al. J. Cell Biol. 179(2):321-330(2007)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
Zick, A., et al. Nucleic Acids Res. 33(13):4235-4242(2005)