PBD-150CAS号： 790663-33-1分子式： C15H20N4O2S 分子量： 320.40描述纯度储存/保存方法可溶性/溶解性In vivo(体内研究)
| 产品描述 | |
| 描述 |
PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO : 125 mg/mL (390.13 mM; Need ultrasonic)
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| 生物活性 | |
| In vivo(体内研究) |
PBD-150 is able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals.
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分子结构图
